The EuroTech Working Group on Chemistry and Chemical Engineering is continuing its online seminar series: In a bi-weekly rhythm, the group is offering a one-hour talk open to all. Join us on 1 June 2022 for the twelfth talk:
Professor Sandrine Gerber-Lemaire
Group for Functionalized Biomaterials, École Polytechnique Fédérale de Lausanne
Harmonic nanoparticles (HNPs), which are composed by non-centrosymmetric inorganic nanocrystals presenting a highly efficient non-linear response, have recently emerged in multiphoton imaging applications with the aim of overcoming some limitations of fluorescent probes. In particular, HNPs exhibit several favorable properties for bioimaging applications, including coherent emission, absence of bleaching/blinking when excited within the material transparency range and wide spectral flexibility. In addition, the possibility to colocalize the simultaneously emitted second and third harmonic signals upon excitation in the shortwave infrared windows make HNPs promising probes for cell monitoring applications in tissues. Taking advantage of these properties, we recently demonstrated the suitability of HNPs (BiFeO3, BFO or LiNbO3, LNO) to be coated with a silica shell and post-functionalized with targeting ligands or molecular payloads for cancer cell and tissue imaging, stem cell tracking and on-demand uncaging applications. Herein, we present effective NIR light responsive nanocarriers based on LNO HNPs conjugated to anticancer drugs and analogues, targeting neoplastic cells and the tumor microenvironment. Another recent development of functionalized LNO HNPs made use of covalent conjugation with Gd3+ chelates for dual optical and magnetic resonance imaging. The design of tailored surface chemical modifications of HNPs paves the way toward theranostic nanoplatforms combining diagnosis capacity with on-demand controlled drug delivery and treatment monitoring through multimodal imaging capabilities.
Professor Sandrine Gerber-Lemaire
Group for Functionalized Biomaterials, École Polytechnique Fédérale de Lausanne
Surface Functionalization of Harmonic Nanoparticles for Multimodal Imaging and Drug Release Applications
AbstractHarmonic nanoparticles (HNPs), which are composed by non-centrosymmetric inorganic nanocrystals presenting a highly efficient non-linear response, have recently emerged in multiphoton imaging applications with the aim of overcoming some limitations of fluorescent probes. In particular, HNPs exhibit several favorable properties for bioimaging applications, including coherent emission, absence of bleaching/blinking when excited within the material transparency range and wide spectral flexibility. In addition, the possibility to colocalize the simultaneously emitted second and third harmonic signals upon excitation in the shortwave infrared windows make HNPs promising probes for cell monitoring applications in tissues. Taking advantage of these properties, we recently demonstrated the suitability of HNPs (BiFeO3, BFO or LiNbO3, LNO) to be coated with a silica shell and post-functionalized with targeting ligands or molecular payloads for cancer cell and tissue imaging, stem cell tracking and on-demand uncaging applications. Herein, we present effective NIR light responsive nanocarriers based on LNO HNPs conjugated to anticancer drugs and analogues, targeting neoplastic cells and the tumor microenvironment. Another recent development of functionalized LNO HNPs made use of covalent conjugation with Gd3+ chelates for dual optical and magnetic resonance imaging. The design of tailored surface chemical modifications of HNPs paves the way toward theranostic nanoplatforms combining diagnosis capacity with on-demand controlled drug delivery and treatment monitoring through multimodal imaging capabilities.
Practical information
Date: Wednesday, 1 June 2022
Time: 15:00-16:00 CET
Location: Zoom link
Registration: is not required
Audience
This event is open to all.
Contact
If you have any questions, please contact Professor Fausto Gallucci of Eindhoven University of Technology.
